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Missing gene makes prostate cancer more aggressive

2/24/2010

Research suggests that prostate cancer is more likely to spread and become more aggressive if a specific gene known as DAB2IP quits functioning.

New research gathered from researcher at UT Southwestern Medical Center suggests that prostate cancer is more likely to spread and become more aggressive if a specific gene known as DAB2IP quits functioning.

Studies have found that various prostate cancer cells can be held in check by the DAB2IP cell, and that when this gene is involved, it prevents other proteins that are present in the development of prostate cancer from becoming over-active.

When the DAB2IP gene stops functioning normally and cells lose this gene, they are able to break free and begin to metastasize and spread to other areas of the body, thus increasing the risk that the cancer will spread to other areas of the body – other organs, lymph system and/or bloodstream.

The study which was published in the Proceedings of the National Academy of Sciences, found that when DAB2IP was eliminated from human carcinoma cells it caused them to change to mesenchymal cells – a sign of metastatic cancer. Cells that have undergone this change have the ability to move easily throughout the body – when the gene is restored it seems as though it reverses the ability to metastasize. Researchers believe that by identifying this gene it can act as a bio-marker aiding physicians in identifying patients with aggressive prostate cancer.

View a complete abstract of this article in Proceedings of the National Academy of Science.

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