Benign prostatic hyperplasia (BPH) and prostatitis can also increase the amount of PSA found in a man's blood. BPH, a non-cancerous enlargement of the prostate, can elevate PSA levels because a larger prostate manufactures more prostate-specific antigen. Also, any prostate condition can weaken the tissues in the prostate gland, allowing more PSA to leak into the blood. Usually, PSA levels caused by BPH do not go as high as those caused by prostate cancer, nor do the levels tend to rise as quickly. However, most likely, if you have a higher than normal PSA level or one that is steadily rising, your doctor will discuss the value of having a prostate biopsy to determine whether cancer or some other condition is to blame.