Perfecting Mice Models to Better Understand Prostate Cancer

Dr. Jim Xuan (1999, 2000 and 2002 Research Grants)

Mice are an important part of medical research because they are physiologically very similar to humans and have the same cancer incidence (30 per cent).

By creating genetically modified mice that mimic genetic alterations and human disease progression, scientists can test theories of causes and treatment of prostate cancer. The more closely a mouse model mimics human cancer, the faster it will lead to new treatments.

Dr. Jim Xuan has been awarded three Foundation grants for his work with mice models. In addition to developing new mouse models for prostate cancer, they have created a blood biomarker that helps monitor the initiation and progress of cancer in mice. They have also developed new three-dimensional technology that allows researchers to see what is happening inside the mice. Previously, the only way to evaluate effectiveness of therapy was during autopsy. Now researchers can see the effects of their interventions while mouse models are alive.



Plaid for Dad


Subscribe to our free monthly e-newsletter!

* indicates required

 





 
PCC Spotlight
Honouring dad this Father’s Day the Canadian way: In plaid

TORONTO, ON – (May 8, 2018) – Plaid replaces business-casual on Friday, June 15 as hundreds of thousands of Canadians don the iconic Canadian attire all to honour dad and end prostate cancer.
More

The Finger – A tried and true method to save lives

TORONTO, CANADA (May 8, 2018) – Every day, more and more methods to detect prostate cancer are being explored, but the tried and true methods of a digital rectal examination (DRE) – where a healthcare professional inserts a gloved finger into the rectum to check for abnormalities, paired with a blood test known as the prostate-specific antigen (PSA) test – which you can get through your family doctor, are still the long-standing proven ways to save a life.
More

Landmark study links tumour evolution to prostate cancer severity

Toronto (April 19, 2018) – Findings from Canadian Prostate Cancer Genome Network (CPC-GENE) researchers and their collaborators, published today in Cell, show that the aggressiveness of an individual prostate cancer can be accurately assessed by looking at how that tumour has evolved.
More


Click here for news archive